Anniversary issue has great cartoonists interviewing each other: Art Spiegelman and Kevin Huizenga. Zak Sally and Jaime Hernandez. Dash Shaw and David Mazzucchelli. Ted Rall and Matt Bors. Jim Borgman and Keith Knight. Ho Che Anderson and Howard Chaykin. Also, Frank Quitely, Dave Gibbons, Sammy Harkham, Denny O'Neil, Matt Fraction, Stan Sakai, and Alison Bechdel. Noah Van Sciver conducts a cartoon interview with Mr. Fantagraphics himself, Gary Groth.

Letters
Blood & Thunder (p. 8)
News
Journal Datebook (p. 10)
Interviews
Art Spiegelman & Kevin Huizenga (p. 24)
Jean-Christophe Menu & Sammy Harkham (p. 56)
Frank Quitely & Dave Gibbons (p. 68)
David Mazzucchelli & Dash Shaw (p. 88)
Alison Bechdel & Danica Novgorodoff (p. 118)
Howard Chaykin & Ho Che Anderson (p. 124)
Denny O'Neil & Matt Fraction (p. 144)
Jaime Hernandez & Zak Sally (p. 168)
Ted Rall & Matt Bors (p. 180)
Jim Borgman & Keith Knight (p. 200)
Stan Sakai & Chris Schweizer (p. 220)
Reviews
"Acme Novelty Library #19" (p. 236)
"Asterios Polyp" (p. 240)
Columns
Rich Kreiner, "Meet the Comics Press" (p. 246)
R. Fiore, "Funnybook Roulette"
Matthias Wivel, Continental Drift
R.C. Harvey, Comicopia
Bill Randall, Lost in Translation
Tom Crippen, Post-Human Review
Coming Comics (p. 285)
Illustrations
Noah Van Sciver, A Cartoon Interview With Gary Groth (p. 19)