Another one and done hardcover printing from Dark Horse. Out of print and surprisingly scarce.

From the publisher:

This eight-time Eisner Award-winning comic book series blending fantasy and humor features the adventures of paranormal pets investigating the monsters of Burden Hill.

The dogs and cats protecting Burden Hill from supernatural harm find themselves facing new threats and mysteries, including a vengeful demon, an invisible killer and an enigmatic flock of lost sheep. As a growing evil threatens to overwhelm their town, the animals find themselves some unlikely allies, most notably a seasoned paranormal investigator named...Hellboy.

This volume collects the comic-book series Beasts of Burden: Sacrifice, Beasts of Burden: Neighborhood Watch, Beasts of Burden: Hunters and Gatherers, Beasts of Burden: What the Cat Dragged In, and Beasts of Burden: The Presence of Others #1 and #2.